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Interleukin 15 (IL-15) is a molecule produced by immune and intestinal cells that is considered to be a central regulator of celiac disease and a driver of lymphoma growth in refractory celiac disease type II (RCD-II).
In diet non-responsive celiac disease, IL-15 appears to be an essential activation factor for the intra epithelial lymphocytes (IELs), which destroy the gut mucosa.
In RCD-II, IL-15 is increased in the intestinal mucosa and is believe to be involved in the mechanism of the disease.