The Role of IL-15 in Celiac Disease and Refractory Celiac Disease

Interleukin 15 (IL-15) is a molecule produced by immune and intestinal cells that is considered to be a central regulator of celiac disease and a driver of lymphoma growth in refractory celiac disease type II (RCD-II).

In diet non-responsive celiac disease, IL-15 appears to be an essential activation factor for the intra epithelial lymphocytes (IELs), which destroy the gut mucosa.

In RCD-II, IL-15 is increased in the intestinal mucosa and is believe to be involved in the mechanism of the disease.

Abadie V, Jabri B. IL-15: a central regulator of celiac disease immunopathology. Immunol Rev 2014; 260:221-234.

Malamut G, El Machhour R, Montcuquet N, Martin-Lannerée S, Dusanter-Fourt I, Verkarre V, et al. IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis. J Clin Invest 2010; 120:2131-2143.

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